1-benzyl 2-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate
Z-Pro-OtBu
CAS: 16881-39-3
Molecular Formula: C17H23NO4
1-benzyl 2-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate - Names and Identifiers
| Name | Z-Pro-OtBu |
| Synonyms | Z-Pro-OtBu Z-L-PRO-OTBU Z-L-PROLINE T-BUTYL ESTER N-CBZ-L-PROLINE T-BUTYL ESTER N-CBZ-L-PROLINE TERT-BUTYL ESTER N-Cbz-L-proline tert-butyl ester N-CARBOBENZOXY-L-PROLINE TERT-BUTYL ESTER N-Benzyloxycarbonyl-L-proline tert-butyl ester N-ALPHA-CARBOBENZOXY-L-PROLINE ALPHA-T-BUTYL ESTER 1-benzyl 2-tert-butyl pyrrolidine-1,2-dicarboxylate N-ALPHA-BENZYLOXYCARBONYL-L-PROLINE-TERT-BUTYL ESTER 1-benzyl 2-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID ALPHA-T-BUTYL ESTER |
| CAS | 16881-39-3 |
| EINECS | 240-911-2 |
| InChI | InChI=1/C17H23NO4/c1-17(2,3)22-15(19)14-10-7-11-18(14)16(20)21-12-13-8-5-4-6-9-13/h4-6,8-9,14H,7,10-12H2,1-3H3/t14-/m0/s1 |
1-benzyl 2-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate - Physico-chemical Properties
| Molecular Formula | C17H23NO4 |
| Molar Mass | 305.37 |
| Density | 1.151±0.06 g/cm3(Predicted) |
| Melting Point | 45 °C |
| Boling Point | 51 °C / 1mmHg |
| Flash Point | 198.6°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 9.22E-07mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| pKa | -3.40±0.40(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.532 |
| MDL | MFCD00051777 |
1-benzyl 2-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
1-benzyl 2-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate - Introduction
Z-Pro-OtBu is an organic compound that contains amino acid residues and benzyloxycarbonyl groups in its chemical structure. The following is a description of its nature, use, preparation and safety information:
Properties: Z-Pro-OtBu is a white solid, soluble in some organic solvents such as methanol and dichloromethane. It has a certain stability, but it may decompose under light and high temperature conditions.
Application: Z-Pro-OtBu is often used as a reagent in organic synthesis. It can be used as a protecting group to protect the amino group in the amino acid. In addition, it can also be used in biomedical research and pharmaceutical fields for the synthesis and exploration of drugs.
Preparation method: The preparation of Z-Pro-OtBu is generally obtained by reacting L-proline with benzyloxycarbonyl tert-butyl carbonate. The specific synthesis steps need to be operated by the Organic Synthesis Laboratory and carried out in accordance with the operating procedures.
Safety Information: The Z-Pro-OtBu has less impact on humans and the environment under normal conditions of use. However, since it is a chemical, it still needs to be handled with care. During use and storage, care should be taken to avoid contact with skin, eyes and inhalation of gas. Appropriate personal protective equipment, such as lab gloves and glasses, should be worn during operation. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Local waste disposal regulations should be followed when disposing of waste.
Properties: Z-Pro-OtBu is a white solid, soluble in some organic solvents such as methanol and dichloromethane. It has a certain stability, but it may decompose under light and high temperature conditions.
Application: Z-Pro-OtBu is often used as a reagent in organic synthesis. It can be used as a protecting group to protect the amino group in the amino acid. In addition, it can also be used in biomedical research and pharmaceutical fields for the synthesis and exploration of drugs.
Preparation method: The preparation of Z-Pro-OtBu is generally obtained by reacting L-proline with benzyloxycarbonyl tert-butyl carbonate. The specific synthesis steps need to be operated by the Organic Synthesis Laboratory and carried out in accordance with the operating procedures.
Safety Information: The Z-Pro-OtBu has less impact on humans and the environment under normal conditions of use. However, since it is a chemical, it still needs to be handled with care. During use and storage, care should be taken to avoid contact with skin, eyes and inhalation of gas. Appropriate personal protective equipment, such as lab gloves and glasses, should be worn during operation. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Local waste disposal regulations should be followed when disposing of waste.
Last Update：2024-04-09 21:04:16
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CAS: 16881-39-3
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CAS: 16881-39-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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